FOTO Santiago Palma 03

PALMA, Santiago Daniel

Farmacéutico
Bioquímico
Dr. en Ciencias Químicas

Lab. 209 – 2º Piso – Edificio Ciencias 2
Haya de la Torre esq. Medina Allende
Ciudad Universitaria, 5000, Córdoba,
Argentina.

telephone +54 351 5353865 Int: 53363
mail sdpalma@fcq.unc.edu.ar
mail sdpalma@gmail.com

Posición Académica

Profesor Asociado (DE – por concurso) del Departamento de Farmacia, FCQ-UNC
Investigador Independiente, UNITEFA-CONICET

Disciplina de Investigación

Disciplinas principales

Ciencias Farmacéuticas.
Tecnología farmacéutica.
Plataformas de liberación de fármacos
Nanotecnología.

Descripción de las actividades científicas desarrolladas:

“Diseño, Desarrollo y Evaluación in vitro/in vivo de nuevas plataformas  de liberación de fármacos (PLFs)”

Abordajes actuales:

Aumento de la permeación y/o retención de fármacos de uso oftalmológico mediante estrategias nanotecnológicas.

Modificación de los patrones de liberación/absorción de Fármacos antiparasitarios utilizando sistemas nanoparticulados.

Aumento de la eficacia de  CpG – DNA administrado en cristales líquidos liotrópicos.

Publicaciones Científicas

[1]– Palma S. D., Manzo R. H., Allemandi D. A. “Dry plant extracts loaded on fumed silica for direct compression: Preparation and preformulation”. Pharmaceutical Development and Technology. 1999; 4 (4): 523-30.

[2]– Jimenez-Kairuz A., Palma S., Manzo R., Allemandi D. “Artificial tears used in Argentina: Evaluation of properties related to formulation”. Acta Farmaceutica Bonaerense. 2000; 19 (1): 53-8.

[3]– Palma S., Lo Nostro P., Manzo R., Allemandi D. “Evaluation of the surfactant properties of ascorbyl palmitate sodium salt”. European Journal of Pharmaceutical Sciences. 2002; 16 (1-2): 37-43.

[4]– Palma S., Luján C., Llabot J. M., Barboza G., Manzo R. H., Allemandi D. A. “Design of Peumus boldus tablets by direct compression using a novel dry plant extract”. International Journal of Pharmaceutics. 2002; 233 (1-2): 191-8.

[5]– Palma S., Manzo R. H., Allemandi D., Fratoni L., Lo Nostro P. “Coagels from ascorbic acid derivatives”. Langmuir. 2002; 18 (24): 9219-24.

[6]– Palma S., Manzo R. H., Allemandi D., Fratoni L., Nostro P. L. “Solubilization of hydrophobic drugs in octanoyl-6-O-ascorbic acid micellar dispersions”. Journal of Pharmaceutical Sciences. 2002; 91 (8): 1810-6.

[7]– Lo Nostro P., Ninham B. W., Ambrosi M., Fratoni L., Palma S., Allemandi D., et al. “Hofmeister effect in coagels of ascorbic acid based surfactants”. Langmuir. 2003; 19 (23): 9583-91.

[8]– Lo Nostro P., Ninham B. W., Fratoni L., Palma S., Manzo R. H., Allemandi D., et al. “Effect of water structure on the formation of coagels from ascorbyl-alkanoates”. Langmuir. 2003; 19 (8): 3222-8.

[9]– Palma S., Hilario Manzo R., Allemandi D., Fratoni L., Lo Nostro P. “Drugs solubilization in ascorbyl-decanoate micellar solutions”. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2003; 212 (2-3): 163-73.

[10]– Palma S., Jiménez-Kairuz A., Fratoni L., Lo Nostro P., Manzo R., Allemandi D. “Coagels from alkanoyl-6-O-ascorbic acid derivatives as drug carriers: Structure and rheology”. Farmaco. 2003; 58 (12): 1271-6.

[11]– Palma S., Manzo R., Lo Nostro P., Fratoni L., Allemandi D. “Vehiculization of Anthralin into n-alkyl Ascorbic Acid Derivatives Coagels”. Acta Farmaceutica Bonaerense. 2003; 22 (4): 305-12.

[12]– Ambrosi M., Lo Nostro P., Fratoni L., Dei L., Ninham B. W., Palma S., et al. “Water of hydration in coagels”. Physical Chemistry Chemical Physics. 2004; 6 (7): 1401-7.

[13]– Palma S. D., Maletto B., Lo Nostro P., Manzo R. H., Pistoresi-Palencia M. C., Allemandi D. A. “Potential use of ascorbic acid-based surfactants as skin penetration enhancers”. Drug Development and Industrial Pharmacy. 2006; 32 (7): 821-7.

[14]– Llabot J. M., Palma S. D., Manzo R. H., Allemandi D. A. “Design of novel antifungal mucoadhesive films. Part II. Formulation and in vitro biopharmaceutical evaluation”. International Journal of Pharmaceutics. 2007; 336 (2): 263-8.

[15]– Llabot J. M., Palma S. D., Manzo R. H., Allemandi D. A. “Design of novel antifungal mucoadhesive films. Part I. Pre-formulation studies”. International Journal of Pharmaceutics. 2007; 330 (1-2): 54-60.

[16]– Palma M. F., Palma S. D. “Some legal and sanitary considerations about the “morning after pill” in Argentina”. Latin American Journal of Pharmacy. 2007; 26 (2): 307-13.

[17]– Palma S., Manzo R., Lo Nostro P., Allemandi D. “Nanostructures from alkyl vitamin C derivatives (ASCn): Properties and potential platform for drug delivery”. International Journal of Pharmaceutics. 2007; 345 (1-2): 26-34.

[18]– Rasia M., Spengler M. I., Palma S., Manzo R., Lo Nostro P., Allemandi D. “Effect of ascorbic acid based amphiphiles on human erythrocytes membrane”. Clinical Hemorheology and Microcirculation. 2007; 36 (2): 133-40.

[19]– Tártara I., Kairuz A. J., Allemandi D. A., Palma S. D. “Rational use of sanitary technologies: Treatment of glaucoma”. Latin American Journal of Pharmacy. 2008; 27 (2): 297-302.

[20]– Palma S. D., Tartara L. I., Quinteros D., Allemandi D. A., Longhi M. R., Granero G. E. “An efficient ternary complex of acetazolamide with HP-ß-CD and TEA for topical ocular administration”. Journal of Controlled Release. 2009; 138 (1): 24-31.

[21]– Saino V., Chetoni P., Palma S., Allemandi D. “Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of ibuprofen through hairless mouse skin”. Latin American Journal of Pharmacy. 2009; 28 (3): 438-42.

[22]– Benedini L., Messina P. V., Manzo R. H., Allemandi D. A., Palma S. D., Schulz E. P., et al. “Colloidal properties of amiodarone in water at low concentration”. Journal of Colloid and Interface Science. 2010; 342 (2): 407-14.

[23]– Castro S. G., Bruni S. S., Lanusse C. E., Allemandi D. A., Palma S. D. “Improved albendazole dissolution rate in pluronic 188 solid dispersions”. AAPS PharmSciTech. 2010; 11 (4): 1518-25.

[24]– Higa V. M., Correa Salde V., Ravetti S., Arce Miranda J. E., Fonsfria L., Palma S. D., et al. “Prescription and Dispensation of Medicines for Hipothyroid Patientsin Córdoba city, Argentina”. Latin American Journal of Pharmacy. 2010; 29 (6): 976-83.

[25]– Saino V., Monti D., Burgalassi S., Tampucci S., Palma S., Allemandi D., et al. “Optimization of skin permeation and distribution of ibuprofen by using nanostructures (coagels) based on alkyl vitamin C derivatives”. European Journal of Pharmaceutics and Biopharmaceutics. 2010; 76 (3): 443-9.

[26]– Tàrtara I., Llabot J. M., Allemandi D. A., Palma S. D. “Dry eye syndrome”. Atencion Farmaceutica. 2010; 12 (3): 172-81.

[27]– Benedini L., Fanani M. L., Maggio B., Wilke N., Messina P., Palma S., et al. “Surface phase behavior and domain topography of ascorbyl palmitate monolayers”. Langmuir. 2011; 27 (17): 10914-9.

[28]– Benedini L., Schulz E. P., Messina P. V., Palma S. D., Allemandi D. A., Schulz P. C. “The ascorbyl palmitate-water system: Phase diagram and state of water”. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2011; 375 (1-3): 178-85.

[29]– Dib A., Palma S., Suárez G., Farías C., Cabrera P., Castro S., et al. “Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs”. Journal of Veterinary Pharmacology and Therapeutics. 2011; 34 (2): 136-41.

[30]– Llabot J. M., Sanchez N. V., Palma S. D., Manzo R. H., Allemandi D. A., Alovero F. L. “Improved biopharmaceutical performance and antifungal efficacy of mucoadhesive films with nystatin”. Pharma Research. 2011; 5 (2): 193-205.

[31]– Palma S. D., Salomon C. J. “Report from the 1st Annual RICiFA Meeting (International Meeting on Pharmaceutical Sciences 2010)”. AAPS PharmSciTech. 2011: 1-2.

[32]– Palma S. D., Salomon C. J. “Report from the 1st annual RICiFA meeting (International Meeting on Pharmaceutical Sciences 2010)”. AAPS PharmSciTech. 2011; 12 (2): 795-6.

[33]– Real J. P., Tártara I., Allemandi D., Granero G., Palma S. D. “Treatment of age-related macular degeneration”. Atencion Farmaceutica. 2011; 13 (3): 160-71.

[34]– Spengler M. I., Rasia M., Palma S., Allemandi D. “Effects of ascorbate fatty ester derivatives on erythrocyte membrane lipoperoxidation”. Clinical Hemorheology and Microcirculation. 2011; 47 (3): 163-8.

[35]– Benedini L., Messina P. V., Palma S. D., Allemandi D. A., Schulz P. C. “The ascorbyl palmitate-polyethyleneglycol 400-water system phase behavior”. Colloids and Surfaces B: Biointerfaces. 2012; 89 (1): 265-70.

[36]– Calles Javier A., Vallés Enrique M., Llabot J. M., Palma S. D. “Solid polymer-based devices for ophthalmic application”. Atencion Farmaceutica. 2012; 14 (2): 116-22.

[37]– Castro S. G., Ramírez-Rigo M. V., Allemandi D. A., Palma S. D. “New binary solid dispersion of indomethacin and croscarmellose sodium: Physical characterization and in vitro dissolution enhancement”. Journal of Excipients and Food Chemicals. 2012; 3 (4): 121-8.

[38]– Gallo L., Ramírez-Rigo M. V., Piña J., Palma S., Allemandi D., Bucalá V. “Valeriana officinalis dry plant extract for direct compression: Preparation and characterization”. Scientia Pharmaceutica. 2012; 80 (4): 1013-26.

[39]– Real J. P., Palchik V., Salamano M., Traverso M. L., Palma S. D. “Off-label use of medicines in Argentina. Who wins and who loses?”. Pharmaceuticals Policy and Law. 2012; 14 (2-4): 209-22.

[40]– Tártara L. I., Quinteros D. A., Saino V., Allemandi D. A., Palma S. D. “Improvement of acetazolamide ocular permeation using ascorbyl laurate nanostructures as drug delivery system”. Journal of Ocular Pharmacology and Therapeutics. 2012; 28 (2): 102-9.

[41]– Calles J. A., Tártara L. I., Lopez-García A., Diebold Y., Palma S. D., Vallés E. M. “Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy”. International Journal of Pharmaceutics. 2013; 455 (1-2): 48-56.

[42]– Castro S. G., Dib A., Suarez G., Allemandi D., Lanusse C., Sanchez Bruni S., et al. “Comparative plasma exposure of albendazole after administration of rapidly disintegrating tablets in dogs”. BioMed Research International. 2013; 2013.

[43]– Castro S. G., Sanchez Bruni S. F., Urbizu L. P., Confalonieri A., Ceballos L., Lanusse C. E., et al. “Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions”. Pharmaceutical Development and Technology. 2013; 18 (2): 434-42.

[44]– Elissondo M. C., Bermudez J. M., Gamboa G. V. U., Pensel P. E., Cid A. G., Juárez M. M., et al. “Hydatid disease: Current status of chemotherapy and drug delivery systems”. Current Drug Therapy. 2013; 8 (3): 197-205.

[45]– Gonzalez Vidal N. L., Starkloff W. J., Bentancor S., Castro S., Suarez G., Palma S. D. “Comparative dissolution studies of Albendazole oral suspensions for veterinary use”. Dissolution Technologies. 2013; 20 (4): 27-30.

[46]– Mora M. J., Tártara L. I., Onnainty R., Palma S. D., Longhi M. R., Granero G. E. “Characterization, dissolution and in vivo evaluation of solid acetazolamide complexes”. Carbohydrate Polymers. 2013; 98 (1): 380-90.

[47]– Palma S. D., Ullio Gamboa G. V., Allemandi D. A. “Vitamin C based nanostructures: Potential utility in ocular and transdermal therapy”. Journal of Biomaterials and Tissue Engineering. 2013; 3 (1): 61-9.

[48]– Real J. P., Luna J. D., Urrets-Zavalia J. A., De Santis M. O., Palma S. D., Granero G. E. “Accessibility as a conditioning factor in treatment for exudative age-related macular degeneration”. European Journal of Ophthalmology. 2013; 23 (6): 857-64.

[49]– Starkloff W. J., Palma S. D., Gonzalez-Vidal N. L. “Nanosuspensions: Particle size reduction as tool to improve lipophilic drugs bioavailability”. Revista Mexicana de Ciencias Farmaceuticas. 2013; 44 (4): 7-16.

[50]– Agotegaray M., Palma S., Lassalle V. “Novel chitosan coated magnetic nanocarriers for the targeted diclofenac delivery”. Journal of Nanoscience and Nanotechnology. 2014; 14 (5): 3343-7.

[51]– Benedini L., Antollini S., Fanani M. L., Palma S., Messina P., Schulz P. “Study of the influence of ascorbyl palmitate and amiodarone in the stability of unilamellar liposomes”. Molecular Membrane Biology. 2014; 31 (2-3): 85-94.

[52]– Bermudez J. M., Cid A. G., Ramírez-Rigo M. V., Quinteros D., Simonazzi A., Sánchez Bruni S., et al. “Challenges and opportunities in polymer technology applied to veterinary medicine”. Journal of Veterinary Pharmacology and Therapeutics. 2014; 37 (2): 105-24.

[53]– López A., Castro S., Andina M. J., Ures X., Munguía B., Llabot J. M., et al. “Insecticidal activity of microencapsulated Schinus molle essential oil”. Industrial Crops and Products. 2014; 53: 209-16.

[54]– Montefuscoli A. R., Werdin González J. O., Palma S. D., Ferrero A. A., Fernández Band B. “Design and development of aqueous nanoformulations for mosquito control”. Parasitology Research. 2014; 113 (2): 793-800.

[55]– Pensel P. E., Castro S., Allemandi D., Bruni S. S., Palma S. D., Elissondo M. C. “Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis”. Veterinary Parasitology. 2014; 203 (1-2): 80-6.

[56]– Quinteros D., Vicario-De-La-Torre M., Andrés-Guerrero V., Palma S., Allemandi D., Herrero-Vanrell R., et al. “Hybrid formulations of liposomes and bioadhesive polymers improve the hypotensive effect of the melatonin analogue 5-MCA-NAT in rabbit eyes”. PLoS ONE. 2014; 9 (10).

[57]– Quinteros D. A., Tártara L. I., Palma S. D., Manzo R. H., Allemandi D. A. “Ocular delivery of flurbiprofen based on Eudragit® E-flurbiprofen complex dispersed in aqueous solution: Preparation, characterization, in vitro corneal penetration, and ocular irritation”. Journal of Pharmaceutical Sciences. 2014; 103 (12): 3859-68.

[58]– Real J. P., De Santis M., Salde V. C., Arce J., Paraje G., Palma S. D. “Profile of oral contraceptive use in the city of Córdoba, Argentina”. Ars Pharmaceutica. 2014; 55 (2): 33-41.

[59]– Real J. P., Gracia Vásquez S. L., Formica M. L., Palma S. D. “Challenges and opportunities related to health promotion in community pharmacies: Obstacles and professional perspectives”. Pharmaceuticals Policy and Law. 2014; 16 (3-4): 313-20.

[60]– Real J. P., Granero G. E., De Santis M. O., Juarez C. P., Palma S. D., Kelly S. P., et al. “Rate of vision loss in neovascular age-related macular degeneration explored”. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2014; 253 (11): 1859-65.

[61]– Salomon C. J., Palma S. D. “Report from the 2nd annual RICiFa meeting (International Meeting on Pharmaceutical Sciences 2012)”. AAPS PharmSciTech. 2014; 15 (2): 497-8.

[62]– Sánchez Vallecillo M. F., Ullio Gamboa G. V., Palma S. D., Harman M. F., Chiodetti A. L., Morón G., et al. “Adjuvant activity of CpG-ODN formulated as a liquid crystal”. Biomaterials. 2014; 35 (8): 2529-42.

[63]– Tártara L. I., Palma S. D., Allemandi D., Ahumada M. I., Llabot J. M. “New mucoadhesive polymeric film for ophthalmic administration of acetazolamide”. Recent Patents on Drug Delivery and Formulation. 2014; 8 (3): 224-32.

[64]– Vidal N. L. G., Castro S. G., Sanchez Bruni S. F., Allemandi D. A., Palma S. D. “Albendazole solid dispersions: Influence of dissolution medium composition on in vitro drug release”. Dissolution Technologies. 2014; 21 (2): 42-7.

[65]– Formica M. L., Calles J. A., Palma S. D. “Polysaccharide-based nanocarriers for ocular drug delivery”. Current Pharmaceutical Design. 2015; 21 (33): 4851-68.

[66]– González A., Tártara L. I., Palma S. D., Alvarez Igarzabal C. I. “Crosslinked soy protein films and their application as ophthalmic drug delivery system”. Materials Science and Engineering C. 2015; 51: 73-9.

[67]– Pensel P. E., Ullio Gamboa G., Fabbri J., Ceballos L., Sanchez Bruni S., Alvarez L. I., et al. “Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice”. Acta Tropica. 2015; 152: 185-94.

[68]– Sánchez Vallecillo M. F., Minguito De La Escalera M. M., Aguirre M. V., Ullio Gamboa G. V., Palma S. D., González-Cintado L., et al. “A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein”. Journal of Controlled Release. 2015; 214: 12-22.

[69]– Ullio-Gamboa G. V., Llabot J. M., Sanchez-Vallecillo M. F., Maletto B. A., Palma S. D., Allemandi D. A. “Development and validation of a high performance liquid chromatography method for oligodeoxynucleotides determination in a novel coagel-based formulation”. Analytical Chemistry Research. 2015; 4: 20-4.

[70]– Bermudez J., Davies C., Simonazzi A., Pablo Real J., Palma S. “Current drug therapy and pharmaceutical challenges for Chagas disease”. Acta Tropica. 2016; 156: 1-16.

[71]– Calles J. A., López-García A., Vallés E. M., Palma S. D., Diebold Y. “Preliminary characterization of dexamethasone-loaded cross-linked hyaluronic acid films for topical ocular therapy”. International Journal of Pharmaceutics. 2016; 509 (1-2): 237-43.

[72]– Calles J. A., Ressia J. A., Llabot J. M., Vallés E. M., Palma S. D. “Hyaluronan–itaconic acid–glutaraldehyde films for biomedical applications: Preliminary studies”. Scientia Pharmaceutica. 2016; 84 (1): 61-72.

[73]– Díaz A. G., Quinteros D. A., Gutiérrez S. E., Rivero M. A., Palma S. D., Allemandi D. A., et al. “Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis”. Veterinary Immunology and Immunopathology. 2016; 178: 50-6.

[74]– Díaz A. G., Quinteros D. A., Llabot J. M., Palma S. D., Allemandi D. A., Ghersi G., et al. “Spray dried microspheres based on chitosan: A promising new carrier for intranasal administration of polymeric antigen BLSOmp31 for prevention of ovine brucellosis”. Materials Science and Engineering C. 2016; 62: 489-96.

[75]– Gamboa G. V. U., Palma S. D., Lifschitz A., Ballent M., Lanusse C., Passirani C., et al. “Ivermectin-loaded lipid nanocapsules: toward the development of a new antiparasitic delivery system for veterinary applications”. Parasitology Research. 2016; 115 (5): 1945-53.

[76]– Huerta J. T., Bermudez J. M., Quinteros D. A., Allemandi D. A., Palma S. D. “New trends, challenges, and opportunities in the use of nanotechnology in restorative dentistry”.  “Nanobiomaterials in Dentistry: Applications of Nanobiomaterials”. 112016. p. 133-60.

[77]– Paredes A. J., Llabot J. M., Sánchez Bruni S., Allemandi D., Palma S. D. “Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying”. Drug Development and Industrial Pharmacy. 2016; 42 (10): 1564-70.

[78]– Quinteros D. A., Ferreira L. M., Schaffazick S. R., Palma S. D., Allemandi D. A., Cruz L. “Novel Polymeric Nanoparticles Intended for Ophthalmic Administration of Acetazolamide”. Journal of Pharmaceutical Sciences. 2016; 105 (10): 3183-90.

[79]– Starkloff W. J., Bucalá V., Palma S. D., Gonzalez Vidal N. L. “Design and in vitro characterization of ivermectin nanocrystals liquid formulation based on a top–down approach”. Pharmaceutical Development and Technology. 2016: 1-9.